Property | Value |
Name | Interaction of Risperidone with testosterone in patient of psychosis. |
Description | Original article:- Vijaywargia Tarun1*, Sharma Gopal2 & Madhusudan Swarnkar3 1Associate professor, Department of Pharmacology, 2Associate professor, Department of Anatomy, 3Assistant professor, Dept of PSM, Jhalawar medical college, Jhalawar, Rajasthan, India.
Abstract: Background– In the series of clinical studies conducted to evaluate effect of male sex hormone Testosterone in patient of schizophrenia(most common psychosis) and the way this hormone interact with anti-psychotic drugs , this was second study conducted by department of pharmacology in collaboration with department of Clinical Psychiatry. In this study the second generation anti-psychotic drug Risperidone is used. The aim of study focused to prove testosterone is useful adjuvant in schizophrenia and can be safely used with anti-psychotic drugs Risperidone. Methods – a. Design and Setting - Double-blind, RCT performed in Indian patients diagnosed of schizophrenia from Feb 2003 to March 2004 in teaching Hospital associated with M.G.M.M.C Indore. b. Subjects:-12 patients aged 20 to 60 years diagnosed schizophrenics according to ICD-10 Criteria, visited in outpatient department of Clinical psychiatry during study period. c. Pharmacological Interventions:- All patients were treated with oral Risperidone 2mg BD, in half of the 12 patient’s single dose of testosterone 100mg intramuscularly also administered. d. Measurement of patient outcomes:– validated psychiatric rating scales are used to evaluated the effect of pharmacological interventions on symptomology of schizophrenic patients .Scales used in clinical study are Brief psychiatric Rating Score (BPRS) , Scale for assessment of positive symptom(SAPS),and Scale for Assessment of Negative Symptoms (SANS). The data is recorded, reported and than analyzed with a help of statistician. Results: - Single dose of 100 mg I.M. initially testosterone potentiated the reduction level in negative symptoms of schizophrenia by 112% in Risperidone 2mg BD. Conclusion:- In this study, testosterone potentiated the effects of Risperidone 2mg BD on general psychotic manifestations, positive symptoms and negative symptoms of schizophrenia, as assessed on BPRS, SAPS and SANS scoring scales, specifically the major effect is on negative symptoms of schizophrenia. There is no increase in side effects as compared to control group.
Key words- Testosterone, Schizophrenia, Risperidone. References:- 1.Jaspers K General Psychopathology .Baltimore M.D: The johns Hopkins University Press; 1997. 2.Kaplan HI, sadock’s BJ, comprehensive Glossary of psychiatry and psychology.Baltimore, MD: Williams and Wilkins; 1995. 3.Brady N, McCain GC. Living with schizophrenia: a family perspective. Online J Issues Nurs 2004; 10:7. 4.Crow TJ: the Two syndrome concept: origins and current status .schizophr Bull. 1985; 11: 471 5.Myers K , Winters NC : Ten year review of rating scales. I overview of scale functioning, psychometric properties, and selection, J Am Acad child Adolesc Psychiatry -2002; 41:114. 6.Kahn RS and Devis KL: New developments in dopamine and schizophrenia. In Psychopharmacology: The fourth generation of progress (ed.) F.E. Bloom and DJ Kupter. Raven Press, New York 1995; 1193-204. 7.Coyle JT, TsaiG, Goff D. Converging evidence of NMDA receptor hypofunction in the Pathophysiology of schizophrenia. Ann J Y Acad Sci.2003; 1003:318. 8.Griffin JE, Ojeda SR: Text book of Endocrine Physiology, New York, Oxford University Press 1996;1017-8. 9.Shores TJ, Miesegaes G: Testosterone in utero and at birth dictates how stressful experience will affect learning in adulthood. Proc Natl Acad Sci USA 2002 Oct 15;99(21):13955-60. 10.Louissaint A Jr., Rao S, Leventhal C, Goldman SA: Coordinated interaction of neurogenesis and angio-genesis in adult song bird brain. Neuron 2002 Jun 13;34(6):945-60. 11.Frye CA, Rhodes ME, Walt A, Harney JP: Testosterone enhances aggression of wild-type mice but not those deficient in type 1 – 5 alpha reductase. Brain Res 2002 Sep 6;948(1-2):165-70. 12.Bart JM, Van Uljmen H, Belindra HOF, Marc J, Mol TM, Hans Van der Boom, Andre Van der Zee, Rune R, Frants, Marten H Holker and Lovis M.: Havekes effect of androgens on growth of right and left cerebral hemispheres and also growth of brain cells primarily used in thinking, behavioral and neuron. Biology 1988; 49:344. 13.Pope HG Jr, Katz DL: psychiatric and medical effects of anabolic –androgenic steroid use .Arch Gen Psychiatry. 1994; 51:375. 14.Kulkarni J, Riedel A, de Castella AR, Fitzgerald PB, Ralfe TJ, Taffe J, Burger: A clinical trial of adjunctive estrogen treatment in women with schizophrenia. Arch Women Ment Health Nov 2002;5(3):99-104. 15.Anthony decastella, Alan Booth DA Granger: The effect of schizophrenia on sex hormones blood levels. Psychiatric Services 2002; 53:600-03. 16.Eto K, Kimura H: The production of hydrogen sulfide is regulated by testosterone and S-Adenosyl-L-methionine in mouse brain. J Neurochem 2002 Oct; 83(1):80-6. 17.E B Strauss, D E Sands, A M Robinson, W J Tindall, W A H Stevenson Dehydroisoandrosterone in Psychiatric Treatment ,British medical journal 08/1952; 2(4775):64-6.Source: PubMed.
Copyright © 2013 Vijaywargia Tarun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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