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Review article:- * D.R.Brahma Reddy1, Chattu.V.Sesha Sai Ram 2 , T.Saravan Kumar3, Kattamuri.S.Bharat kumar 4, Vaka.Yalamanda Reddy5, Ch.Taraka Lalitha Kumari6.
1.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
2.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
3.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
4.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
5.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
6.Siddharth Institute of Pharmacy, Kantepudi, Guntur, A.P, India.
Abstract:-Drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and biochemical parameters pertinent to their performance. Over the past three decades, Rapimelts have gained considerable attention as a preferred alternative to conventional tablets and capsules due to there better patient compliance. Orally disintegrating tablets offer an advantage for populations who have difficulty in swallowing. Prescription Rapimelts products initially were developed to overcome the difficulty in swallowing conventional tablets with water among pediatric, geriatric, and psychiatric patients with dysphagia. Today, Rapimeltss are widely available as over-the-counter drugs for the treatment of allergies and cold and flu. Technologies used for manufacturing of orally disintegrating tablets are either conventional technologies or patented technologies. Important ingredients that are used in the formulation of Rapimelts should allow quick release of the drug, resulting in faster dissolution. Evaluation of these tablets are done by weight variation, friability, tensile strength, wetting time, water absorption ratio, In vitro dispersion time and. dissolution test.
Keywords:- Rapimelts , Orasolv, Tensile strength, Sublimation, Disintegration, Lyophillisation , Superdisintegrants
Research article:- *Udegbunam, R.I1., Udegbunam, S.O2., Ugwuanyi, S.C3
1.MVSC; Department of Veterinary Surgery, University of Nigeria, Nsukka.
2.MSC; Department of Veterinary Surgery, University of Nigeria, Nsukka.
3.DVM; Department of Veterinary Surgery, University of Nigeria, Nsukka.
Abstract:- The effects of the ethanol extract of Bridelia ferruginea stem bark on wound contraction and epithelization were evaluated in rats. After wound creation, 5% w/w ointment of Bridelia, gentamicin ointment and soft white paraffin were topically applied to the wounds of rats in the treatment groups. The percentage wound contraction of the Bridelia ointment treated rats was significantly higher than those of the base treated groups from day 9 after wounding. Complete epithelization was observed by day 18.2 ± 0.4 in the rats treated with the ointment of B. ferruginea. It was concluded that Bridelia ferruginea significantly enhanced wound contraction and epithelization. This finding provides further scientific evidence in support of its ethno medicinal use for wound healing.
Keywords:- Bridelia ferruginea, ethanol, gentamicin, excision wound, ointment.
Original research article:- *,Autamashih Musa (M. Sc) 1 Isah Adamu B (Ph. D)1, Allagh Teriyila S (Ph. D)1, Ibrahim Musa A (Ph. D, Professor)2
1.Department of Pharmaceutics and Pharm. Micro., Faculty of Pharm. Sciences, Ahmadu Bello University, Zaria, Nigeria.
2.Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharm. Sciences, University of Jos,Nigeria.
Abstract Context:- Leaves of Vernonia galamensis have been used for ages in folk medicine for the treatment of diabetes mellitus. The crude leaves extract is highly hygroscopic and deliquescent and efforts to use the common diluents; lactose, maize starch and magnesium carbonate for tablet formulation was futile as very poor quality tablets with many defects especially ‘sticking’ and ‘picking’ were produced. To counteract this deliquescent property, an efflorescent diluent; hydrophobic fumed silica, was carefully selected for the formulation. Aim: To investigate the effect of hydrophobic fumed silica in the tablet formulation of the deliquescent crude extract of Vernonia galamensis using selected standard binders. Materials and Methods: Materials included; hydrophobic fumed silica (Aerosil® R9200, Evonic Industries AR, Germany), maize starch and gelatin (May and Baker, Germany). Granule and tablet analyses were carried out according to standard procedures in the BP 2007. The mechanical strengths of tablets were assessed using the crushing strength-friability, disintegration time ratio (CSFR:DT) and the drug release properties using dissolution times. Statistical analysis: GraphPad Prism® version 5.03 software was used. Results and conclusions: An increase in binder concentration led to an increase in crushing strength, decrease in friability and increase in disintegration time of the tablets. Fumed silica used as diluent along with gelatin as binder produced the best quality tablets in terms of the CSFR:DT ratio and dissolution rate.
Key words:- Diabetes mellitus, Fumed silica, Vernonia galamensis.