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Case Report
Jayabal Pandiaraja1*, Devadhason Darwin Britto2
1 Assistant Professor, Department of General Surgery, SRM Medical College,
Kancheepuram district, Tamil Nadu 603203, India
2 Assistant Professor, Department of General Surgery, SRM Medical College,
Kancheepuram district, Tamil Nadu 603203, India
Address reprint requests to
*Dr. Pandiaraja,
26/1 Kaveri Street,
Rajaji Nagar, Villivakkam, Tamil Nadu, Chennai, India
Article citation: Pandiaraja J, Darwin Britto D. An uncommon feature of papillary thyroid carcinoma: a case report. J Pharm Biomed Sci 2015;05(11):828–830. Available at www.jpbms.info
ABSTRACT
Most of the thyroid malignancies occur in either euthyroid or hypothyroid status. Thyroid malignancies with hyperthyroidism are very rare. There are numerous reasons for hyperthyroidism in thyroid cancer. The incidence of hyperthyroidism in thyroid malignancies
were <1%. But recent report showed increased incidence due to mutation of thyroid receptors. The problem with hyperthyroidism and thyroid cancer was diagnostic difficulty and management part, because for most of the cases of hyperthyroidism thyroid malignancies
are not suspected. This is a case report of papillary thyroid carcinoma presenting in hyperthyroid patient who has diagnostic difficulty and management.
KEYWORDS papillary thyroid carcinoma, hyperthyroidism, total thyroidectomy
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in
discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense. The manuscript is original and is not published or communicated for publication elsewhere either in part or full.
Original article
Famurewa Ademola C1*,Kanu Shedrach C1,Uzoegwu Peter N2,Ogugua Victor N2
1 Department of Medical Biochemistry,Faculty of Basic Medical Sciences, Federal University, Ndufu-Alike, Ikwo, Ebonyi,Nigeria
2 Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria,Nsukka
Address reprint requests to
*Famurewa, Ademola, Clement,
Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Federal University, Ndufu-Alike, Ikwo,Ebonyi State, Nigeria.
Abstract:
Objective: Hibiscus sabdariffa is a medicinal plant associated with beneficial health effects.The leaves and flowers are used as traditional drinks and medicines in countries. The current study aimed to investigate H. sabdariffa L. methanolic extract ameliorative potential against carbon tetrachloride-induced lipid peroxidation, hepatic damage and oxidative stress.
Methods Adult male Wistar rats were administered 2.5 ml/kg body weight of CCl4 by oral gavage to induce oxidative stress 48 hours before administration of 200, 600 to 1000 mg/kg doses of H. sabdariffa methanolic extract to group 3, 4 and 5, respectively for 10 days (n = 5). Group 1 was used as negative control, while group 2 was used as positive-comparative control (2.5 ml/kg CCl4). At the end of the experiment, serum glutathione (GSH), vitamin C and E, MDA, liver damage markers and antioxidant enzymes were analysed in all the groups. Results Carbon tetrachloride-induced oxidative stress in experimental rats was evidenced by increase in malondialdehyde (MDA) and reduction in SOD, catalase and reduced glutathione (GSH). H. sabdariffa extract treatment at 600 and 1000 mg/kg doses resulted in significant modulation of antioxidant indices and alkaline phosphatase (p < 0.05), but failed to demonstrate significant effects in AST, ALT and MDA. There were significant increases (p < 0.05) in the serum vitamin C and E at 600 and 1000mg/kg doses of the extract.Conclusion The overall results suggest that H. sabdariffa contains bioactive phytochemicals that may improve hepatic status and ameliorate oxidative damage at high doses in carbon tetrachloride intoxication.
KEYWORDS Hibiscus sabdariffa, hepatic damage, lipid peroxidation, oxidative stress,phytochemicals
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.Source of funding: None.
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense. The manuscript is original and is not published or communicated for publication elsewhere either in part or full.