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Original article
Eduard Circo*,Olesea Scrinic
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*Dr Eduard Circo,
Department of Endocrinology, Faculty of Medicine, “Ovidius” University of Constanta, Campus Corp B, Aleea Universitatiinr. 1, Constanta, Romania
Article citation:
Circo E, Scrinic O.Correlation between osteocalcin, non-HDL cholesterol and metabolic syndrome in postmenopausal women. J Pharm Biomed Sci 2016;06(08):498–501.Available at www.jpbms.info
Background Osteoporosis, cardiovascular diseases (CVD), and metabolic syndrome (MS) are associated with a higher mortality rate. Bone tissues, adipocytes, and the brain interact together to control body weight and regulate glucose metabolism through osteocalcin (OC), a hormone secreted by the osteoblasts. The aim of our study was to establish the correlation between serum osteocalcin levels, features of MS and cardiovascular risk assessed through non-HDL-cholesterol levels in a group of postmenopausal women.
Methods Retrospective study conducted over a period of 3 years on a group of 150 postmenopausal women, divided into two lots according to the presence or absence of MS. The diagnosis of MS was made based on NCEP ATP - III criteria. Serum osteocalcin has been correlated with specific components of MS and other atherogenic markers.
Results OC values were lower in patients with MS compared to those without MS. Significant negative correlations were recorded between OC and the fasting values of blood glucose, body mass index (BMI), and triglyceride levels. The most accurate atherogenic risk parameter non-HDL-cholesterol was significantly and negatively correlated with OC. Positive and significant correlations were recorded between the values of HDL-cholesterol and OC (R² = 0.033; P < 0.05). All these results sustain the significant association between dyslipidemia,
the alteration of glucose metabolism, and OC in postmenopausal women with MS.
Conclusions The correlation between pro-atherogenic lipid fractions (non-HDL cholesterol) and osteocalcin is of real interest. Low serum values of osteocalcin may represent a metabolic marker of cardiovascular risk.
KEYWORDS cardiovascular risk, non-HDL-cholesterol, osteocalcin, metabolic syndrome
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Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
RESEARCH ARTICLE
Rahul Bagul*,Krishan Yadav,Ankit Rai,Sanjay Deo,Vivek Patole
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*Dr. Rahul R. Bagul, Department of Orthopaedics, Padmashree Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India
Article citation: Bagul R, Yadav K, Rai A, Deo S, Patole V. Comparative study of functional outcome in Colles’ fracture treated conservatively by closed reduction and cast and closed reduction, Kirschner wire and cast. J Pharm Biomed Sci 2016;06(08):464–468.Available at www.jpbms.info
ABSTRACT
Displaced Colles’ fractures are generally treated by closed reduction and below elbow cast application. Malunion is a common complication resulting in pain, mid carpal instability and post-traumatic arthritis. Fracture stabilization by Kirschner wire is a simple, minimally invasive technique, which helps to prevent displacement of the fracture thereby minimizing complications.
Aim To study comparative evaluation of functional outcome in Colles’ fracture treated conservatively by closed reduction and cast and closed reduction, Kirschner wire and cast.
Materials and Methods Thirty adult patients with Colles’ fracture were assigned into two groups after informed consent. Group 1 cases were treated with closed reduction and plaster cast application, and Group 2 cases were treated with closed reduction, Kirschner wire and plaster cast application. The functional outcome of cases was assessed by Mayo wrist score (0 to 100 points) as modified by Cooney and Bussey and the functional as well as radiological outcome were assessed by the Demerit scoring system modified by Saito.
Results According to Mayo functional score in Group 1, we had 2 good, 10 satisfactory and 3 poor results, and in Group 2, we had 8 excellent results, 6 good and 1 satisfactory
results. According to a Modified demerit point system of Saito in Group 1, we had 12 fair and 3 poor results and in Group 2 we had 9 excellent and 6 good results.
Conclusion We conclude that percutaneous Kirschner wire pinning is a minimally invasive technique that provides an effective method of maintaining fracture reduction.
KEYWORDS Colles’ fracture, cast, Kirschner wire
Statement of originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research.
All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Original article
R. Manivannan1,G. Puviarasan2*
1 Assistant professor of surgery, Madras Medical College, MMC, Park Town, Chennai, Tamil Nadu 600003
2 Resident In Surgery, Madras Medical College, MMC, Park Town, Chennai, Tamil Nadu 600003
Address reprint requests to:
*Dr. G. Puviarasan,
Resident In Surgery, Madras Medical College, MMC, Park Town, Chennai, Tamil Nadu 600003
Article citation: R. Manivannan,G. Puviarasan. Clinical study and management of liver injuries due to blunt trauma abdomen. J Pharm Biomed Sci 2016;06(08):489–494.Available at www.jpbms.info
Abstract
Background This study is carried out to assess the impact of liver injuries in blunt trauma abdomen, the etiology and various modes of presentations of liver injuries due to blunt trauma abdomen and to evaluate various available investigation to detect liver injuries and appropriate management strategy to reduce mortality and morbidity and their common complications.
Materials and Methods The study population consist of all cases with suspected blunt trauma abdomen presenting to the Surgical Department, Rajiv Gandhi Govt. General Hospital between May 2012 and December 2013. It is an observational cross sectional study involving 52 patients. All the patients included in this study were investigated with FAST (Focused assessment of sonography for trauma), DPL Diagnostic peritoneal lavage, Contrast CT abdomen and other base line investigations. Their hemodynamic stability is taken in to account before these investigations are done. Penetrating trauma and paediatric patients are excluded from this study.
Results The most common cause of blunt injury abdomen is road traffic accidents (69.23%) which are comparable to most other studies. In the present study, the maximum number of cases was in the second decade of life (25%). In the present study, 80(80%) were males and 20(20%) were females. Out of 52 cases in our study, (90%) had abdominal tenderness at the time of admission, local (or) generalized guarding was present in 11.5% cases. In our study, 11(21.15%) were managed surgically and 41(78.86%) were managed conservatively. We had mortality of 12 cases of which eight were operated cases.
Conclusion Hemodynamic status and associated injuries, irrespective of grading form the most important factor that decides the nature of treatment for a particular patient. So the treatment has to be tailor made for every patient.
KEYWORDS liver injuries, blunt trauma and liver injuries
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8.Chopra P, St-Vu D, Yazbeck S. Blunt renal trauma-blessing in disguise? J Pediatr Surg. 2002;37(5):779–782.
9.McAninch JW, Santucci R. Renal injuries chapter 1 1A in adult and pediatric urology, Fourth edition, Lippincott Williams and Wilkins, Philadelphia. USA. 2002;479–498.
Source of funding: None.
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents, and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.