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Review article:- *Amartya De, Prof. (Dr.) N.N Bala, Abhijit Bhattacharjee.
Department of Pharmacology, B.C.D.A College OF Pharmacy & Technology, 78 Jessore road (s), Hridaypur, Barasat, Kolkata-700127, West Bengal, India.
Abstract:- Glioblastoma multiforme is an aggressive disabling and deadly disease of the central nervous system. Early detection and treatment improve the prognosis for adults with glioblastoma. Advance practice nurses can help identify patients with glioblastoma multiforme early in the disease process and provide these patients with comprehensive nursing care.In this article we discuss the clinical presentation, diagnosis, postoperative care, treatment, symptom management, health promotion and physicochemical care for patients with glioblastoma multiforme.
Keywords:- Brain tumor, Glioblastoma Multiforme, Glial Cells, Pharmacological Treatment.
Research article:- *Nagdeote A.N.1, Dange N. S.2, Deshpande K. A.3 and Pawade Y. R. 4.
1Associate professor in Biochemistry, Department of Biochemistry, ESI Post Graduate Institute of Medical Sciences and Research, Andheri east, Mumbai , Maharashtra, India. 2Associate professor in Biochemistry, Government Medical College, Jagdalpur, Chhattisgarh, India.
3Assistant Professor in Biochemistry, Government Medical College, Nagpur, Maharashtra, India.
4Assistant Professor in Biochemistry and clinical nutrition Seth G S Medical College & KEM Hospital, Parel, Mumbai, Maharashtra, India.
Abstract:- Calcium and magnesium exert a major role upon diverse physiological process. Defect in calcium homeostasis have been seen in the asthma process. Antagonism of calcium and magnesium in the asthma and the beneficial effect of magnesium therapy in asthma have also been found in many studies. Children being the major target of asthma, we studied the blood levels of ionized calcium, total calcium, magnesium, sodium and potassium in 50 asthmatic children attending the pediatric OPD and compared with similar number of age and sex matched control. It was found that there was significant decrease in the levels of serum ionized calcium (1.15 ± 0.01 mmol/L), total calcium (8.93 ± 0.96mg/dl) and serum magnesium (1.91 ± 0.23 mg/dl)in asthmatic children as compare to the normal controls (1.24 ± 0.01 mmol/L), (9.35 ± 0.90 mg/dl) and (2.05 ± 0.23 mg/dl) respectively. The significant decrease was irrespective with the age, gender of patients and the severity of disease. In study group serum sodium (138 ± 3.4 mmol/L) and potassium (4.13 ± 0.46 mmol/L) showed no significant difference as compared to normal control group (139 ± 3.4 mmol/L) and (4.2 ± 0.53 mmol/L) respectively. A defect in calcium homeostasis may lead to increased utilization and translocation i.e. higher influx of calcium ions in bronchial smooth muscle cells and variety of other cells for e.g. mast cells which might have caused its lowering in plasma, ionized calcium being a physically active fraction which account for nearly half of the total calcium levels. These results suggest that airway hyper-responsiveness may be associated with altered calcium mobilization in airway smooth muscles. Utilization of magnesium for antagonism of calcium in the asthma process might have caused significant lowering in serum magnesium levels in asthmatic children as compare to normal controls.
Key words:- asthma, hyper-reactivity, ionized calcium, magnesium.
Research article:- *R P Mishra1, Deepak2, Surya Pratap Singh2 & Raheel Anwar2.
1R & D Division, MRD LifeSciences, Lucknow, Uttar Pradesh, India.
2Stani Memorial P. G. College, Jaipur, Rajasthan, India.
Abstract:- Infections caused by drug resistant microorganisms result in significant increase in mortality, morbidity and cost related to prolonged treatments. To check the virulence and sensitivity towards drugs, a brief knowledge of culture conditions and nutritional requirements are needed. This study includes the culture optimization and nutritional evaluation of the Acinetobacter baumannii under different pH, media components and also the effect of different drugs. Intra & extracellular extracts obtained from the culture proved very good response against other virulent pathogens, thus a controlled culturing under strict observations can lead to an innovative antimicrobial components to be used as health care drug in future.
Keywords:- Acinetobacter baumannii, antimicrobial activity, MIC, E. coli, S. aureus, C. albicans MRSRA 1102 MH.
Letter to the editor:-
*Dr. M. Dheepa1, Dr. B. Appalaraju2, Ms. S. Chithra 3.
1Associate Professor, Department of Microbiology, PSG Institute of Medical Sciences & Research , Peelamedu, Coimbatore- 641004, Tamil Nadu, India.
2Professor and Head, Department of Microbiology, PSG Institute of Medical Sciences & Research , Peelamedu, Coimbatore- 641004, Tamil Nadu, India.
3PSG Institute of Medical Sciences & Research, Peelamedu, Coimbatore- 641004, Tamil Nadu, India.
Original research article:- *Buch Pankaj M1, Parmar Parin2, Doshi Smita K3, Chudasama Rajesh K4.
1M.D. (Pediatrics) ,Professor, Department of Pediatrics, M P Shah Medical College, Jamnagar, Gujarat, India.
2M.D. (Pediatrics) , Assistant Professor, Department of Pediatrics, P D U Medical College, Rajkot, Gujarat, India.
3M.D. (Pediatrics), Professor & Head Department of Pediatrics, P D U Medical College, Rajkot, Gujarat, India.
4M.D. (Community Medicine) , Associate Professor, Department of Community Medicine, M P Shah Medical College, Jamnagar, Gujarat, India.
Abstract:- Objective: To evaluate possible predictors of immediate outcome in non-traumatic coma in children with infective etiology. Method: An observational prospective study was conducted over a period of 15 months from 1st June 2009 to 31st August 2010 at Department of Pediatrics, Government Medical College, Rajkot, Gujarat, India. Children aged 6 months to 12 years presenting with non-traumatic coma with history, clinical features and laboratory studies suggestive of infective etiology were followed upto immediate outcome. A complete history, general and systemic examination at presentation was recorded. Relevant laboratory and radiological investigations were performed and GCS was recorded every 6 hourly until the immediate outcome. The etiology of coma was determined on the basis of history, clinical examination and investigations. Results: CNS infections (n=34), Respiratory tract infections (n=26) and sepsis (n=34) were most common etiology of non traumatic coma. Severe malnutrition and Anemia were comman associated conditions. Thirty Eight (40.4%) survived and Fifty six patients (59.6%) died. survival was better with Meningitis compared to sepsis (p=0.007). GCS <5 on admission, Shock on presentation, Hypothermia, associated severe Malnutrition and significant anemia, Severe dehydration,, abnormal breathing Pattern, Nonreactive Pupils and jaundice correlated significantly with mortality. On logistic regression poor pulse volume, GCS at 24 hrs <5, CNS infection, Jaundice; severe dehydration and significant Anemia were independent significant predictors of death. Conclusion: CNS infections, Respiratory infections and sepsis were most comman cause of non traumatic coma. Shock and Severe Malnutrition contributes to adverse outcome. Simple clinical signs and GCS were good predictors of outcome.
Keywords:- Non-traumatic coma in children, infective etiology, Predictors of mortality.