March 2015;05(10) issue of the J Pharm Biomed Sci.
DocumentsDate added
Original article
Samir Golder1,*,Shanta Nibedita Satpathy1,¥, Rajesh Kumar Padhy1,¥,Rajlaxmi Panigrahi1,¥, Swarupjit Ghata1
Affiliation:
1Third Year P.G Student, 1,¥M.S, Department of Otorhinolaryngology, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Otorhinolaryngology, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India
Address reprint requests to
Dr. Samir Golder.
3rd year PG student,
Department of Otorhinolaryngology, Hi- Tech Medical College and Hospital, Bhubaneswar, Odisha, India
Article citation:
Golder S, Satpathy SN, Pandhy RK, Panigrahi R, Ghata S. A clinicopathological study of solitary thyroid nodule. J Pharm Biomed Sci. 2015; 05(03):233-237. Available at www.jpbms.info
ABSTRACT:
Background: Solitary thyroid nodule is defined as presence of a palpable nodule in otherwise normal thyroid gland. Solitary nodules are one of the commonest presentations of thyroid disorder.
Aims and objectives: To study the age and sex incidence and other clinical parameters of solitary thyroid nodules and to correlate between fine needle aspiration cytology (FNAC) and histopathological examination of solitary nodule thyroid.
Material and methods: A prospective study had been carried out from November 2012 to October 2014, in the Otorhinolaryngology department, of Hi-tech Medical College & Hospital, Bhubaneswar, Odisha, India. Fifty patients, who presented with confirmed solitary thyroid swelling and underwent some form of thyroid surgery were included in this study. Complete history was taken and full clinical examination was carried out.
Results: Majority of the patients were between 30-49 years of age. Female:male ratio was about 9:1. Swelling in front and lateral side of neck was the most common presentation. Most common solitary thyroid swelling was colloid goiter. Commonest surgery performed was hemithyroidectomy.
Conclusion: Fine needle aspiration cytology (FNAC) was the first investigation of choice. Fine needle aspiration cytology (FNAC) is easy, cheap, highly sensitive and specific method to diagnose lesions of solitary thyroid nodule.
KEYWORDS: Solitary nodule thyroid; fine needle aspiration cytology (FNAC); thyrid nodule histopathological examination.
REFERENCES
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Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Golder S,Satpathy SN,Pandhy RK,Panigrahi R,Ghata S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Khokan Bera1,2,*,Jasmina Khanam2, Bhaskar Mazumder3
Affiliation:-
1Assistant Professor, Calcutta Institute of Pharmaceutical Technology & AHS. Uluberia, W.B.,India
2Professor, Department of Pharmaceutical Technology, Jadavpur University, W.B., India
3Assistant Professor, Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Calcutta Institute of Pharmaceutical Technology & AHS. Uluberia, W.B.,India
2.Department of Pharmaceutical Technology, Jadavpur University, W.B., India
3.Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India
Address reprint requests to
Khokan Bera
Calcutta Institute of Pharmaceutical Technology & AHS. Uluberia-711316, W.B., India
Article citation:
Bera K, Khanam J, Mazumder B. An analytical method development By liquid chromatography-mass spectrometry for the analysis of samples in in vivo study of a controlled release formulation, glipizide-pectin beads. J Pharm Biomed Sci.2015;05(03):223-232.Available at www.jpbms.info
ABSTRACT
A simple, sensitive and stable analytical LC/MS/MS (API 2000, Applied Biosystem Sciex) method has been developed and validated for rapid identification and quantification of antidiabetic drug, glipizide in blood plasma of wistar rats fed with a new formulation of glipizide-pectin beads. Samples containing glipizide were analyzed on C18-column (50 x 4.6mm, 5µm) using mixture of 0.01% (v/v) formic acid and methanol in 1:9(v/v) as mobile phase at a flow rate of 0.5 ml/minute. Glimepiride was used as internal standard (IS). Plasma samples were extracted with a mixture of ethyl acetate, dichloromethane, chloroform, isopropyl alcohol (2.5:2.5:3:2, v/v).The organic layer was evaporated to dryness and quantified by LC/MS/MS. Precision was ~10.90 (intra-day) and 9.68 (inter-day). LOD, LOQ, mean recoveries, were observed as 25 ng/ml and 50 ng/ml and 96-99% respectively. This method was found reproducible, precise and rapid (retention time 1.56 minutes) with accuracy of 99.35%.
KEYWORDS: Glipizide, LC/MS, rat plasma, pharmacokinetics, hypoglycaemic.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
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11.Altinoz S, Tekeli D (2001) Analysis of glimepiride by using derivative UV spectrophotometric method. J Pharm Biomed Anal 24(3):507–515.
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Copyright © 2015. Panwar MS, Tanwar YS. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Shams Ul Nisa1,*,Tajinder Kaur Saggu.2,R.Sangeetha.3,Namrata Harchandani4
Affiliation:
1Assistant Professor, Department of Oral Medicine and Radiology. Bharati Vidyapeeth Dental College and Hospital – Pune, Maharashtra, India
2Senior Lecturer, Department of Oral & Maxillofacial Pathology, Dasmesh Institute of Research & Dental Sciences, Faridkot- 151203, Punjab, India
3Reader, Department of Oral Medicine and Radiology, Ragas Dental College and Hospital- Chennai, India
4M.D.S, Dental Practioners, Department of Oral Medicine and Radiology, Pune, Maharashtra, India
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Oral Medicine and Radiology, Bharati Vidyapeeth Dental College and Hospita l– Pune, Maharashtra, India
2.Department of Oral & Maxillofacial Pathology, Dasmesh Institute of Research & Dental Sciences, Faridkot- 151203, Punjab, India.
3. Department of Oral Medicine and Radiology. Ragas Dental College and Hospital- Chennai, India
Address reprint requests to
Dr. Shams Ul Nisa.
Assistant Professor, Department of Oral Medicine and Radiology. Bharati Vidyapeeth Dental College and Hospital – Pune.
Address: Room no: 14, Bharati Vidyapeeth Dental College and Hospital, Katraj–Dhankawadi, Pune.Pin code: 411043
Article citation:
Nisa SU, Saggu TK, Sangeetha R, Harchandan N. An unusual case of Odontogenic Keratocyst mimicking Central Giant Cell Granuloma. J Pharm Biomed Sci. 2015; 05(03):243-249. Available at www.jpbms.info
ABSTRACT:
Keratocystic odontogenic tumors (KCOTs) previously known as odontogenic keratocyst are aggressive intraosseous lesion with a recurrence rate of approximately 25-60%. World Health Organization (WHO) defined keratocystic odontogenic tumour (KCOT) as “a benign Unicystic or multicystic, intraosseous tumour of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and potential for aggressive, infiltrative behaviour.” WHO recommends the term “keratocystic odontogenic tumour” as it better reflects its neoplastic nature. KCOTs appear as well defined radiolucencies with distinct sclerotic margins, which can be either unilocular or multilocular. Here, we are presenting a rare case of OKC in anterior mandible crossing midline. The present paper also highlights brief discussion concerning the management of OKC.
KEYWORDS: Odontogenic keratocyst; keratocystic odontogenic tumor; anterior mandible.
REFERENCES
1.Rajkumar GC, Hemalatha M, Shashikala R, Sonal P. Massive keratocystic odontogenic tumor of mandible: A case report and review of literature. Indian Journal of Dental Research 2011; 22(1):181.
2.Jonathan Madras, BSc (Hons), DDS; Henry Lapointe, DDS, PhD, FRCD(C). Keratocystic Odontogenic Tumour: Reclassification of the Odontogenic Keratocyst from Cyst to Tumour. JCDA • www.cda-adc.ca/jcda March 2008;74( 2):165-165h.
3.Ajit Auluck, MDS, Setty Suhas, MDS, Keerthilatha M. Pai, MDS. Multiple Odontogenic Keratocysts: Report of a Case Ajit. C D. JCDA. www.cda-adc.ca/jcda• September 2006;72(7): 651-656.
4. Vij H, Vij R, Gupta V, Sengupta S.Odontogenic keratocyst: A peripheral variant. Niger J Clin Pract 2011;14:504-7.
5.Leite, T. C.; Meirelles Jr., V. & Janini, M. E. R. Odontogenic keratocystic tumor: A clinical and histopathologic retrospective study based on the new WHO classification. Int. J. Odontostomat. 2011; 5(3):227-234.
6. Sulabha A N, Choudhari S, Kenchappa U, Totad S. Massive keratocystic odontogenic tumor of mandible crossing the midline in 11-year child: An unusual case report and its management. Dent Hypotheses 2013;4:28-32.
7.Reddy M, Bela Mahajan, Khatri M ,Desai RS,Duggal A. An Interdental Radiolucent Lesion of Mandible: A Case Report and Differential Diagnosis. Int. Journal of Clinical Dental Science 2011; 2(3):13-17.
8. Moeini et al. A Case Report of Odontogenic Keratocyst in Anterior Mandibule Position. American Journal of Research Communication 2013:1(9):286-289.
9.Anisha Maria, Yogesh Sharma, Amit Chabbria. Marsupialization as a treatment option of a large Odontogenic keratocyst: A case report with the review of literature. People’s Journal of Scientific Research. Jan 2012;5(1):46-51.
10.Vijay Ebenezer, R. Balakrishnan and M. Sivakumar. A Case Report on Surgical Management of Odontogenic Keratocyst. World Journal of Medical Sciences 2014; 10 (2): 212-216.
11. Paul S Bland, Jacob Shiloah, Molly S Rosebush. Journal of the Tennessee Dental Association 2012;92(2):33-6; quiz 37-8.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
Copyright © 2015 Nisa SU, Saggu TK, Sangeetha R, Harchandan N. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Vikramjit Singh Wasu1,*, G. DurgaPadmaja2
Affiliation:
1Professor of Pediatrics, Malla Reddy Institute of Medical Sciences, Hyderabad, India
2Deputy Civil Surgeon, ESI Hospital, Sanat Nagar, Hyderabad, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Malla Reddy Institute of Medical Sciences, Hyderabad,India
2.Deputy Civil Surgeon, ESI Hospital, Sanat Nagar, Hyderabad, India
Address reprint requests to
*Dr. Vikramjit Singh Wasu.
Professor of Pediatrics, Malla Reddy Institute of Medical Sciences, Hyderabad, India
Article citation:
Wasu VS, DurgaPadmaja G. Antiphospholipid antibodies in epilepsy with particular reference to neurocysticercosis in children. J Pharm Biomed Sci. 2015; 05(03):178-181. Available at www.jpbms.info
ABSTRACT:
Background: Some of the partial or uncontrolled epilepsies are associated with antibodies suggesting the existence of epileptic syndromes with possible abnormalities in immunological systems in such patients.
Objective: To determine the incidence of NCC admitted for convulsions with no previous neurological deficits and adverse history along with serum APLA levels in the patients forming study group.
Methods: Children admitted with convulsions in Gandhi Hospital beyond neonatal period up to 18years from January 2009 to April 2010 formed the study group. Children were evaluated by taking clinical history, thorough examination of all systems, followed by array of investigations.
Results: Out of total 70 cases studies, 3 were positive for APLA. APL antibodies were positive in two children with normal CT scan and one child with abnormal CT scan. Generalized seizures were seen in 33 children and partial seizures in 37 children. APL antibodies were positive in two children with partial seizures and one child with generalized seizures. Total of 18 children among 70 children showed neurocysticercosis in radio imaging. Six(6) each of children were found in stage 2 and stage 3. Two (2) children were in stage 1 and three children in stage 4 neurocysticercosis. APL antibodies were positive in one case of neurocysticercosis.
Conclusion: There has been an incidence of 4.2% of APLA positivity in our study. In this study, there is no statistical significance of APLA in epilepsy including symptomatic epilepsy due to neurocysticercosis. Further studies are required to determine exactly which type of seizure is immune mediated.
KEYWORDS: Neurocysticercosis; Antiphospholipid antibodies; epilepsy.
REFERENCES
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8.Ranua JA, Luoma K, Peltola JT, Haapala AM, Isojarvi JI. Auto-antibodies in patients with epilepsy. A cohort based study. Epilepsia 2001;42(S2):20.
9.Eriksson K, Peltola J, Keranan T, Haapala AM, Koivikko M. High prevalence of antiphospholipid antibodies in children with epilepsy: A controlled study of 50 cases. Epilepsy Res 2001;46:129-137.
10.Climex R, Romeo A, Scarano A et al. Prevalence of anticardiolipin, anti beta 2 glycoprotein I and antiprothrombin antibodies in young patients with epilepsy. Epilepsia 2002;43:52-59.
11.Anne GO. Diagnostic neuro radiology 1994. Chapter 16. Infections of the brain and its linings. Pages 710-711.
12.Debourdeau P, Gerome P, Zammit C, Saillol A, Alletti M, Bourgues L et al. Frequency of anticardiolipin, antinuclear and anti beta 2 GP1 antibodies is not increased in unselected epileptic patients. A case control study. Seizures 2004;13(4):205-7.
13.Constantin T et al. Prevalence of antiphospholipid and antinuclear antibodies in children with epilepsy. Med Sci Mont 2009;15(4):164-9.
14.Angelini L, Granata T, Zibordi F, Binelli S, Zorzi G, Besana C. Partial seizures associated with antiphospholipids in childhoos. Neuropediatrics 1998;29(5):249-53.
Source of funding: None
Competing interest / Conflict of interest: The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Statement of Originality of work: The manuscript has been read and approved by all the authors, the requirements for authorship have been met, and that each author believes that the manuscript represents honest and original work.
Disclaimer: Any views expressed in this paper are those of the authors and do not reflect the official policy or position of the Department of Defense.
A multinational study
AsaadJavaidMirza1,*BDS, MCPS, MDS, IrfanUllah Khan2BDS, FCPS, MaazAsad3BDS, MDSc, MarwahBerkath3 BDS, SaadiaSaad4 BDS
Affiliation:
1*Professor, College of Dentistry, University of Ha'il, KSA
2Professor, Department of Operative Dentistry, Margalla Institute of Health Sciences, Islamabad, Pakistan
3Research Scholar, Department of Restorative Dentistry, University of Malaya, Kuala Lumpur, Malaysia
4General Dental Practitioner, Dubai
The name of the department(s) and institution(s) to which the work should be attributed:
1. College of Dentistry, University of Ha'il, KSA
2. Department of Operative Dentistry, Margalla Institute of Health Sciences, Islamabad, Pakistan
3. Department of Restorative Dentistry, University of Malaya, Kuala Lumpur, Malaysia
Address reprint requests to
Prof. Asaad Javaid Mirza
College of Dentistry, University of Ha'il, KSA
Article citation:
Mirza AJ, Khan IU, Asad M, Berkath M, Saad S. Assessment of dentists’ knowledge versus their practices towards treating dental caries. J Pharm Biomed Sci. 2015; 05(03):255-262. Available at www.jpbms.info
ABSTRACT:
Owing to induction of modern technology in dentistry, advent of adhesive restorative materials and better understanding of caries and its prevention modalities, caries treatment has turn out to be less invasive and more effective. Despite having all of the options for caries management at hand, most of the dentists continue to treat caries by traditional drill & fill technique. This can be well observed in Middle Eastern countries where dentists of various nationalities, especially from Asian and African countries come to work in health sector.
This multinational study accomplished in Asian and African countries was done to assess the status of practicing dentists’ knowledge about the modern pathways for caries management and its implementation in their clinical practices. Therefore, the objectives of this study were to assess knowledge of practicing dentists about caries treatment and to assess percentage of the dentists following modern caries- treating strategies.
Material & Methods: A meticulously prepared user-friendly questionnaire was displayed on social media consisting of 12 queries each on dentists’ knowledge about caries management and practice of its clinical implementation.
Results: Dentists from many Asian and African countries participated in the study and 515 responses were received. The data was analyzed using SPSS 17.
Conclusion: Most of the participating dentists lack pragmatic approach towards caries treatment despite having up-to-date pedagogic knowledge about caries management strategies.
KEYWORDS: Caries prevention; Caries management; Caries risk assessment; CAMBRA.
REFERENCES
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7.Pienihäkkinen K, Söderling E, Ostela I, Leskelä I, Tenovuo J. Comparison of the efficacy of 40% chlorhexidine varnish and 1% chlorhexidine-fluoride gel in decreasing the level of salivary mutans streptococci. Caries research. 1995;29(1):62-7.
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Copyright © 2015 Mirza AJ, Khan IU, Asad M, Berkath M, Saad S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.